Maslinic acid in the treatment of heart damage in obesity hypertension through activating Nrf2 pathway

The present study is to explore the interventional effects and potential mechanisms of Maslinic acid on heart damage in obesity hypertension. rats were given SHR high-fat diet for 16 weeks. WGA staining Masson applied detect structure fibrosis degree. WB method was used expressions ANP, BNP, P-MHC, TGF-?1, CTGF, Collagen I, III, Fibronectin other proteins tissue. ELISA serum TNF-?, IL-6, PAI-1 content. IF employed expression Nrf2 can significantly improve morphology tissue, reduce hypertrophy swelling cardiomyocytes, inhibit deposition collagen fibers, MYH7, TGFpl, Fibronectin, CollagenI CollagenIII effectively TNF-a, IL-6 expression, inflammation, elevate level obese SHR, myocardial hypertrophy, cardiac fibrosis, inflammation. underlying mechanism may be related elevating protein cytoplasm promoting enter nucleus, thereby activity mitochondria-function-related proteins. capabilities hypertrophy-related are also related.